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Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to be Held on June 6, 2022 Your Vote Counts! VOYAGER THERAPEUTICS, INC. 2022 Annual Meeting June 6, 2022 9:00 AM ET 64 Sidney Street Cambridge, Massachusetts 02139 VOYAGER THERAPEUTICS, INC. 64 SIDNEY STREET CAMBRIDGE, MA 02139 D84109-P69693 You invested in VOYAGER THERAPEUTICS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 23, 2022 to facilitate timely delivery. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Vote in Advance of the Meeting Vote by June 5, 2022 11:59 PM ET Visit www.ProxyVote.com Vote in Person at the Meeting* Smartphone users Point your camera here and vote without entering a control number Date: Time: June 6, 2022 9:00 AM ET Location: Voyager Therapeutics, Inc. 64 Sidney Street Cambridge, Massachusetts 02139 *Please check the meeting materials for any special requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares. V1.1 For complete information and to vote, visit www.ProxyVote.com Control #

Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items D84110-P69693 Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. 1. To elect the following director to serve as a Class I director until the 2025 Annual Meeting of Stockholders and until his successor is duly elected and qualified. Nominee: 1a. Glenn Pierce For 2. To approve, on a non-binding advisory basis, the compensation of the Company’s named executive officers. For 3. To ratify the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2022. For NOTE: The Board of Directors may also transact such other business as may properly come before the meeting or at any and all adjournments or postponements thereof.