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  <xsd:element id="vygr_CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundNonAlzheimerDisease" name="CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundNonAlzheimerDisease" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_PerformanceMilestones" name="PerformanceMilestones" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_ScheduleOfCashCashEquivalentsAndRestrictedCashTableTextBlock" name="ScheduleOfCashCashEquivalentsAndRestrictedCashTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_ProbablePerformanceMilestones" name="ProbablePerformanceMilestones" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_NonProfitAgreementMember" name="NonProfitAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_PercentageLimitOfIssuedAndOutstandingSharesUpToWhichAdditionalSharesMayBeIssued" name="PercentageLimitOfIssuedAndOutstandingSharesUpToWhichAdditionalSharesMayBeIssued" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_DebtSecuritiesContractualMaturityPeriod" name="DebtSecuritiesContractualMaturityPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_NonStatutoryStockOptionsMember" name="NonStatutoryStockOptionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_VyaadcProgramMember" name="VyaadcProgramMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_DiscoveryProgramOneMember" name="DiscoveryProgramOneMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_DiscoveryProgramTwoMember" name="DiscoveryProgramTwoMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementNumberOfPrograms" name="CollaborativeArrangementNumberOfPrograms" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementNumberOfDiscoveryPrograms" name="CollaborativeArrangementNumberOfDiscoveryPrograms" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementUpfrontPaymentToBeReceived" name="CollaborativeArrangementUpfrontPaymentToBeReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementAggregateMilestonePaymentsIfExerciseRights" name="CollaborativeArrangementAggregateMilestonePaymentsIfExerciseRights" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementPercentageOfProfitOrLossUnderCoCoOption" name="CollaborativeArrangementPercentageOfProfitOrLossUnderCoCoOption" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementTerminationPeriodFromFirstCommercialSale" name="CollaborativeArrangementTerminationPeriodFromFirstCommercialSale" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementPercentageOfReductionInRoyaltyPayments" name="CollaborativeArrangementPercentageOfReductionInRoyaltyPayments" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementPeriodOfAdvanceNoticeForTerminationPriorToFirstCommercialSale" name="CollaborativeArrangementPeriodOfAdvanceNoticeForTerminationPriorToFirstCommercialSale" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementPeriodOfAdvanceNoticeForTerminationAfterFirstCommercialSale" name="CollaborativeArrangementPeriodOfAdvanceNoticeForTerminationAfterFirstCommercialSale" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_NeurocrineBiosciencesIncMember" name="NeurocrineBiosciencesIncMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_DepositsAndOtherNonCurrentAssets" name="DepositsAndOtherNonCurrentAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="vygr_PercentageOfMaximumNetOperatingLossCarryforward" name="PercentageOfMaximumNetOperatingLossCarryforward" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_NumberOfOwnershipChanges" name="NumberOfOwnershipChanges" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_StockIssuedDuringPeriodValueCollaborationAgreement" name="StockIssuedDuringPeriodValueCollaborationAgreement" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vygr_StockIssuedDuringPeriodSharesCollaborationAgreement" name="StockIssuedDuringPeriodSharesCollaborationAgreement" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_EntitledLeaseholdImprovements" name="EntitledLeaseholdImprovements" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="vygr_IncreaseDecreaseInRightOfUseAssets" name="IncreaseDecreaseInRightOfUseAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vygr_CollaborativeArrangementThreeAdditionalResearchCompoundsPaymentToBeReceivedForEach" name="CollaborativeArrangementThreeAdditionalResearchCompoundsPaymentToBeReceivedForEach" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundInCaseOfParkinsonSDiseaseIndication" name="CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundInCaseOfParkinsonSDiseaseIndication" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundInCaseOfFirstIndicationOtherThanParkinsonSDisease" name="CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundInCaseOfFirstIndicationOtherThanParkinsonSDisease" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundNonParkinsonSDisease" name="CollaborativeArrangementMilestonePaymentsToBeReceivedForLicensedCompoundNonParkinsonSDisease" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementSpecifiedCommercialMilestonePayments" name="CollaborativeArrangementSpecifiedCommercialMilestonePayments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_AbbvieTauCollaborationAgreementMember" name="AbbvieTauCollaborationAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_AbbvieAlphaSynucleinCollaborativeArrangementMember" name="AbbvieAlphaSynucleinCollaborativeArrangementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_NeurocrineCollaborativeArrangementMember" name="NeurocrineCollaborativeArrangementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_RevenuePerformanceObligationsAllocationOfVariableTransactionPrice" name="RevenuePerformanceObligationsAllocationOfVariableTransactionPrice" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vygr_RevenuePerformanceObligationsAllocationOfFixedTransactionPrice" name="RevenuePerformanceObligationsAllocationOfFixedTransactionPrice" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vygr_FaProgramMember" name="FaProgramMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementCostsToObtainContract" name="CollaborativeArrangementCostsToObtainContract" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementDiscountRelatedToEquityInvestment" name="CollaborativeArrangementDiscountRelatedToEquityInvestment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementNumberOfTargets" name="CollaborativeArrangementNumberOfTargets" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_RevenuePerformanceObligationAllocationOfVariableTransactionPriceTableTextBlock" name="RevenuePerformanceObligationAllocationOfVariableTransactionPriceTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_RevenuePerformanceObligationAllocationOfFixedTransactionPriceTableTextBlock" name="RevenuePerformanceObligationAllocationOfFixedTransactionPriceTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_DevelopmentAndRegulatoryMilestonesMember" name="DevelopmentAndRegulatoryMilestonesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_OperatingLeaseWeightedAverageIncrementalBorrowingRate" name="OperatingLeaseWeightedAverageIncrementalBorrowingRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="vygr_CollaborativeAgreementEstimatedCostReimbursement" name="CollaborativeAgreementEstimatedCostReimbursement" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_CollaborativeArrangementUpfrontFeePaidOnDateOfTermination" name="CollaborativeArrangementUpfrontFeePaidOnDateOfTermination" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vygr_TerminationAgreementMember" name="TerminationAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementMilestonePayableUponAchievement" name="CollaborativeArrangementMilestonePayableUponAchievement" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_NumberOfNonCentralNervousSystem" name="NumberOfNonCentralNervousSystem" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementUpfrontPaymentMade" name="CollaborativeArrangementUpfrontPaymentMade" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vygr_CollaborativeArrangementMilestonePaymentAgreedToBePaid" name="CollaborativeArrangementMilestonePaymentAgreedToBePaid" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vygr_PeriodInWhichMilestonePaymentWillBeMadeOfFilingOfInvestigationalNewDrug" name="PeriodInWhichMilestonePaymentWillBeMadeOfFilingOfInvestigationalNewDrug" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_PercentageOfThresholdSublicensingIncomeAgreedToBePaid" name="PercentageOfThresholdSublicensingIncomeAgreedToBePaid" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementAmountOfUnusedInKindServicesWaived" name="CollaborativeArrangementAmountOfUnusedInKindServicesWaived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_ThresholdNumberOfCapsidsHavingExclusiveOptionsToEvaluateForNoConsideration" name="ThresholdNumberOfCapsidsHavingExclusiveOptionsToEvaluateForNoConsideration" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_ThresholdAdditionalNumberOfCapsidsHavingOptionsToEvaluateForLowPayment" name="ThresholdAdditionalNumberOfCapsidsHavingOptionsToEvaluateForLowPayment" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_ThresholdNumberOfCapsidsThatHasRightToObtainExclusiveLicense" name="ThresholdNumberOfCapsidsThatHasRightToObtainExclusiveLicense" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementConsiderationReceived" name="CollaborativeArrangementConsiderationReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_IncreaseDecreaseInCollaborationReceivables" name="IncreaseDecreaseInCollaborationReceivables" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vygr_MiscellaneousOtherLiabilitiesNoncurrent" name="MiscellaneousOtherLiabilitiesNoncurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vygr_InducementStockOptionAwardsMember" name="InducementStockOptionAwardsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_DrDinahSahMember" name="DrDinahSahMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_ConsultantDuration" name="ConsultantDuration" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementTotalPayableAmount" name="CollaborativeArrangementTotalPayableAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vygr_SalesMilestoneMember" name="SalesMilestoneMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_RelatedPartyTransactionBoardAndScientificAdvisoryServicesMember" name="RelatedPartyTransactionBoardAndScientificAdvisoryServicesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_FormerExecutivesMember" name="FormerExecutivesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_NumberOfIndividualsProvidingServicesInRelatedPartyTransactions" name="NumberOfIndividualsProvidingServicesInRelatedPartyTransactions" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_ProgramsAddedAtLaterDate" name="ProgramsAddedAtLaterDate" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_CommonStockFutureIssuanceVestingOfRestrictedStockUnitsMember" name="CommonStockFutureIssuanceVestingOfRestrictedStockUnitsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_EmployeeStockPurchase2015PlanMember" name="EmployeeStockPurchase2015PlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_Dr.StevenMPaulMember" name="Dr.StevenMPaulMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_CollaborativeArrangementReimbursableCostsExpectedToBeReceived" name="CollaborativeArrangementReimbursableCostsExpectedToBeReceived" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_DeferredTaxAssetsLeaseLiability" name="DeferredTaxAssetsLeaseLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="vygr_LeaseExchangeCashFlowAmount" name="LeaseExchangeCashFlowAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vygr_CollaborativeArrangementInKindServicesToBeProvidedByCollaborativePartnerMaximumPotential" name="CollaborativeArrangementInKindServicesToBeProvidedByCollaborativePartnerMaximumPotential" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_Facility75HaydenAvenueMember" name="Facility75HaydenAvenueMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_DepositsAndOtherNoncurrentAssetsMember" name="DepositsAndOtherNoncurrentAssetsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_AdditionsToContractWithCustomerAssets" name="AdditionsToContractWithCustomerAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_DeductionsToContractWithCustomerAssets" name="DeductionsToContractWithCustomerAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="vygr_NonProfitOrganizationMilestonePaymentLiability" name="NonProfitOrganizationMilestonePaymentLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="vygr_SidneyStreet75And64LeasesMember" name="SidneyStreet75And64LeasesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="vygr_CommonStockAndWarrantsToPurchaseEquitySecurities" name="CommonStockAndWarrantsToPurchaseEquitySecurities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="vygr_WarrantsToPurchaseEquitySecurities" name="WarrantsToPurchaseEquitySecurities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="vygr_PercentageOfOutstandingCommonStock" name="PercentageOfOutstandingCommonStock" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="vygr_DiscoveryAndFaProgramsMember" name="DiscoveryAndFaProgramsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element name="PfizerMember" id="vygr_PfizerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfTransgenes" id="vygr_NumberOfTransgenes" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DevelopmentRegulatoryAndCommercializationMilestoneMember" id="vygr_DevelopmentRegulatoryAndCommercializationMilestoneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfOptions" id="vygr_NumberOfOptions" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OptionAndLicenseAgreementMember" id="vygr_OptionAndLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeArrangementNumberOfDiscoveryProgramsUnderDevelopment" id="vygr_CollaborativeArrangementNumberOfDiscoveryProgramsUnderDevelopment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LicenseAgreementNumberOfTransgenes" id="vygr_LicenseAgreementNumberOfTransgenes" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LicenseAgreementNumberOfCountriesReceivedRegulatoryApproval" id="vygr_LicenseAgreementNumberOfCountriesReceivedRegulatoryApproval" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LicenseAgreementNumberOfMajorMarketCountriesReceivedRegulatoryApproval" id="vygr_LicenseAgreementNumberOfMajorMarketCountriesReceivedRegulatoryApproval" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LicenseAgreementNumberOfOptionsExercised" id="vygr_LicenseAgreementNumberOfOptionsExercised" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="StockPurchasePlanPayrollPercentDeduction" id="vygr_StockPurchasePlanPayrollPercentDeduction" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RevenuePerformanceObligationsNumberOfPerformanceObligations" id="vygr_RevenuePerformanceObligationsNumberOfPerformanceObligations" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="RevenuePerformanceObligationsNumberOfMaterialRights" id="vygr_RevenuePerformanceObligationsNumberOfMaterialRights" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfLicenseOptions" id="vygr_NumberOfLicenseOptions" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NovartisLicenseAgreementMember" id="vygr_NovartisLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NovartisPharmaAgMember" id="vygr_NovartisPharmaAgMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AdditionalFeeAgreedToPayUnderCollaborativeArrangement" id="vygr_AdditionalFeeAgreedToPayUnderCollaborativeArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
