SEC Form 4 
FORM 4	UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940 	  
OMB APPROVAL
OMB Number:	3235-0287	
Estimated average burden	
hours per response:	0.5	

	
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).			
1. Name and Address of Reporting Person*
Third Rock Ventures III, L.P.	

(Last)	(First)	(Middle)	
C/O THIRD ROCK VENTURES, LLC	
29 NEWBURY STREET, 3RD FLOOR	

(Street) 
BOSTON	MA	02116	

(City)	(State)	(Zip)	
	2. Issuer Name and Ticker or Trading Symbol 
Voyager Therapeutics, Inc. [ VYGR ] 	5. Relationship of Reporting Person(s) to Issuer 
(Check all applicable) 
	Director	X	10% Owner	
	Officer (give title below)		Other (specify below)	

	3. Date of Earliest Transaction (Month/Day/Year)
04/12/2017 		
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) 
	Form filed by One Reporting Person	
X	Form filed by More than One Reporting Person	
	
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned	
1. Title of Security (Instr. 3) 	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8) 	4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 	5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 	7. Nature of Indirect Beneficial Ownership (Instr. 4) 	
			Code	V	Amount	(A) or (D)	Price				
Common Stock	04/12/2017		J(1) 		920,000	D	(1)	9,391,176	D(2) 		
Common Stock								13,122(3) 	D(3) 		
Common Stock								13,122(4) 	D(4) 		
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities) 	
1. Title of Derivative Security (Instr. 3) 	2. Conversion or Exercise Price of Derivative Security 	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8) 	5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 	6. Date Exercisable and Expiration Date (Month/Day/Year)	7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 	8. Price of Derivative Security (Instr. 5) 	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 	11. Nature of Indirect Beneficial Ownership (Instr. 4) 	
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares					
1. Name and Address of Reporting Person*
Third Rock Ventures III, L.P.	

(Last)	(First)	(Middle)	
C/O THIRD ROCK VENTURES, LLC	
29 NEWBURY STREET, 3RD FLOOR	

(Street) 
BOSTON	MA	02116	

(City)	(State)	(Zip)	
	
1. Name and Address of Reporting Person*
Third Rock Ventures GP III, L.P.	

(Last)	(First)	(Middle)	
29 NEWBURY STREET, 3RD FLOOR	

(Street) 
BOSTON	MA	02116	

(City)	(State)	(Zip)	
	
1. Name and Address of Reporting Person*
TRV GP III, LLC	

(Last)	(First)	(Middle)	
29 NEWBURY STREET, 3RD FLOOR	

(Street) 
BOSTON	MA	02116	

(City)	(State)	(Zip)	
	
1. Name and Address of Reporting Person*
STARR KEVIN P	

(Last)	(First)	(Middle)	
29 NEWBURY STREET, 3RD FLOOR	

(Street) 
BOSTON	MA	02116	

(City)	(State)	(Zip)	
	
1. Name and Address of Reporting Person*
TEPPER ROBERT I	

(Last)	(First)	(Middle)	
29 NEWBURY STREET, 3RD FLOOR	

(Street) 
BOSTON	MA	02116	

(City)	(State)	(Zip)	
	
Explanation of Responses:	
1. Pursuant to a Rule 10b5-1 trading plan adopted by Third Rock Ventures III, L.P. ("TRV III"), Third Rock Ventures GP III, L.P. ("TRV GP III") and TRV GP III, LLC ("TRV GP III LLC"), TRV III distributed on April 12, 2017, for no consideration, 920,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to TRV GP III, the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.	
2. These shares are directly held by TRV III. The general partner of TRV III is TRV GP III. The general partner of TRV GP III is TRV GP III LLC. The individual managers of TRV GP III LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP III, TRV GP III LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares.	
3. These shares are directly held by Starr. Includes Shares received in the distributions described in footnote (1) above.	
4. These shares are directly held by Tepper. Includes Shares received in the distributions described in footnote (1) above.	
Remarks:	
	
	/s/ Kevin Gillis, Chief Financial Officer of TRV GP III, LLC, general partner of Third Rock Ventures GP III, L.P., general partner of Third Rock Ventures III, L.P.	04/14/2017	
	/s/ Kevin Gillis, Chief Financial Officer of TRV GP III, LLC, general partner of Third Rock Ventures GP III, L.P.	04/14/2017	
	/s/ Kevin Gillis, Chief Financial Officer of TRV GP III, LLC	04/14/2017	
	/s/ Kevin Gillis by power of attorney for Kevin Starr	04/14/2017	
	/s/ Kevin Gillis by power of attorney for Dr. Robert Tepper	04/14/2017	
	** Signature of Reporting Person	Date	
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.	
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).	
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).	
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.	
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.