Voyager Therapeutics Announces Multiple Data Presentations at the American Society of Gene and Cell Therapy 2022 Annual Meeting
“We look forward to reporting data at ASGCT 2022 that showcases our broad range of gene therapy expertise that is shaping our portfolio strategy and therapeutic pipeline,” said
Details for the oral and poster presentations are as follows.
CNS Penetrant AAV Vectors Encoding HER2 Antibodies Reduce Tumor Burden in Models of Breast Cancer Brain Metastasis
Summary: A CNS-targeted, TRACER-generated AAV capsid was used to deliver broad brain expression of a vectorized HER2 antibody, which activated the innate immune response with increased tumor-proximal natural killer cells, proliferating microglia, and dendritic cells, and significantly reduced tumor burden in multiple mouse models.
Session: AAV Preclinical CNS Gene Therapy
Location & Time:
Abstract Number: 63
Directed Evolution of AAV9 Peptide Display Libraries Identifies a Family of Cross-Species Variants with Enhanced Brain Tropism in
Summary: A novel, TRACER-generated AAV9 capsid family achieved 50-fold better transduction in mice and 60-fold better transduction in macaques compared to conventional AAV9 with a unique tropism for glial cells.
Session: Novel AAV Capsids for the Brain, Eye and Kidney
Location & Time: Ballroom A,
Abstract number: 1198
All posters will be presented in Hall D,
Directed Evolution of an AAV5 Capsid Library Identifies a Variant with Enhanced Transduction in
Session: AAV Vectors - Virology and Vectorology I
Poster Board Number: M-10
Abstract Number: 129
Development of High Throughput Screening for DOE-Based Formulation Screening
Session: Pharmacology/Toxicology Studies or Assay Development I
Poster Board Number: M-303
Abstract number: 422
Forced Degradation Studies of AAVs to Generate the Full Spectrum Aggregation Toolkit
Session: Vector Product Engineering, Development or Manufacturing I
Poster Board Number: M-269
Abstract number: 388
Development of AAV-GBA1 Gene Replacement Therapy for IV Delivery via Blood Brain Barrier Penetrant AAV Capsid
Session: Gene Targeting and Gene Correction II
Poster Board Number: Tu-71
Abstract number: 566
Structural Analysis of AAV9 Derivatives Produced on Different Production Platforms and Characterization of their Empty Capsids
Session: Vector Product Engineering, Development or Manufacturing II
Poster Board Number: Tu-247
Abstract number: 742
Efficacy of a Novel Vectorized Antibody Targeting the C-Terminal Domain of Tau Using Systemic Dosing of a Blood Brain Barrier Penetrant AAV Capsid in Mouse Models of Tauopathies
Session: Neurologic Diseases III
Poster Board Number: W-157
Abstract number: 1031
Intravenous Delivery of AAV Gene Therapy Provides Broad SOD1 Knockdown in the Spinal Cord and Robust Efficacy in a Mouse Model of SOD1-ALS
Session: Musculo-skeletal Diseases
Poster Board Number: W-187
Abstract number: 1061
About Voyager Therapeutics
This press release contains forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995 and other federal securities laws. The use of words such as “may,” “might,” “will,” “would,” “should,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “undoubtedly,” “project,” “intend,” “future,” “potential,” or “continue,” and other similar expressions are intended to identify forward-looking statements.
For example, all statements Voyager makes regarding the participation of scientists associated with Voyager making presentations at ASGCT 2022, and the presentations of data at ASGCT 2022, the potential for capsids generated by Voyager’s TRACER capsid discovery technology to have a positive impact for gene therapy development and the treatment of patients with medical conditions; and the ability to broaden the application of Voyager’s TRACER platform and establish human proof-of-concept across a range of serious diseases, are forward looking statements.
All forward-looking statements are based on estimates and assumptions by Voyager’s management that, although Voyager believes such forward-looking statements to be reasonable, are inherently uncertain. All forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those that Voyager expected. Such risks and uncertainties include, among others, the final acceptance by the organizers of ASGCT 2022 of submissions presenting Voyager research; the ability of Voyager scientists to effectively deliver their presentations at ASGCT 2022; the continued development by Voyager of various technology platforms, including the TRACER platform; and Voyager’s scientific approach and general development progress.
These statements are also subject to a number of material risks and uncertainties that are described in Voyager’s most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, as updated by its subsequent filings with the Securities and Exchange Commission. All information in this press release is as of the date of this press release, and any forward-looking statement speaks only as of the date on which it was made. Voyager undertakes no obligation to publicly update or revise this information or any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.
Source: Voyager Therapeutics, Inc.